||This work intends to examine a work of art, specifically the Large Glass from Marcel Duchamp, based on the concept of interface. The analysis is based on the spectator’s action and on the conditions that the work establishes in a way that the action updates the work and transforms it continuously. Three points, based on the Large Glass, are proposed for the work of art to organize the spectator’s action creatively: (-) Technology conceived as creation process (-) Virtualization of representative supports, from the internal projections of the spectator. (-) Production of specific subjectivation process. // These aspects can be applied for the reflection on the establishment of creative relationships between utilitarian interfaces and their users.